From: Epigenome-wide association study of total serum immunoglobulin E in children: a life course approach
Participant characteristics | Cord blood DNA methylation data (N = 242) | Mid-childhood DNA methylation data (N = 411) | DNA methylation data at both time points (N = 217) |
---|---|---|---|
Maternal characteristics | |||
Age (years), mean ± SD | 32.0 (5.6) | 32.3 (5.5) | 32.3 (5.4) |
Smoking status, N (%) | |||
 Smoked during pregnancy | 24 (10%) | 41 (10%) | 20 (9%) |
 Former smoker | 53 (22%) | 83 (20%) | 49 (23%) |
 Never smoker | 165 (68%) | 287 (70%) | 148 (68%) |
College graduate, N (%) | |||
 Yes | 158 (65%) | 271 (66%)* | 144 (66%) |
 No | 84 (35%) | 138 (34%) | 73 (34%) |
Atopy history | |||
 Yes | 90 (37%) | 163 (40%)* | 80 (37%) |
 No | 152 (63%) | 246 (60%) | 137 (63%) |
Child characteristics | |||
Gestational age (weeks), mean ± SD | 39.7 (1.6) | 39.6 (1.6) | 39.7 (1.6) |
Age at blood drawn (years), mean ± SD | 7.8 (0.7)†| 7.8 (0.7)†| 7.8 (0.7) |
Sex, N (%) | Â | Â | Â |
 Female | 117 (48%) | 201 (49%) | 105 (48%) |
 Male | 125 (52%) | 210 (51%) | 112 (52%) |
Race/ethnicity, N (%) | |||
 White | 161 (67%) | 256 (62%)†| 143 (66%) |
 Black | 42 (17%) | 77 (19%) | 39 (18%) |
 Other | 39 (16%) | 77 (19%) | 35 (16%) |
Total serum IgE level in mid-childhood, (kU/L) | 146.4 (310.2) | 152.1 (286.2) | 142.5 (311.0) |