| Horvath age acceleration | Hannum age acceleration (EEAA) |
---|
Dependent variable | Beta* | SE |
p
| Beta# | SE |
p
|
---|
LDL mg/dL (0Â h) | 0.36 | 0.21 | 0.09 | 0.166 | 0.12 | 0.17 |
LDL mg/dL (6 h) | 0.003 | 0.06 | 0.96 | − 0.006 | 0.04 | 0.87 |
HDL mg/dL (0 h) | 0.06 | 0.08 | 0.52 | − 0.11 | 0.04 |
0.02
|
HDL mg/dL (6Â h) | 0.05 | 0.03 |
0.05
| 0.004 | 0.15 | 0.81 |
TC mg/dL (0Â h) | 0.44 | 0.25 | 0.08 | 0.091 | 0.14 | 0.52 |
TC mg/dL (6Â h) | 0.15 | 0.08 | 0.06 | 0.068 | 0.05 | 0.13 |
TG mg/dL (0Â h) | 0.001 | 0.004 | 0.75 | 0.002 | 0.002 | 0.30 |
TG mg/dL (6Â h) | 0.0005 | 0.002 | 0.84 | 0.004 | 0.001 |
0.02
|
IL6 (0 h) | − 0.001 | 0.004 | 0.76 | 0.007 | 0.002 |
0.007
|
CRP (0Â h) | 0.007 | 0.008 | 0.34 | 0.018 | 0.004 |
0.0001
|
MCP1 (0 h) | − 0.001 | 0.002 | 0.55 | − 0.0003 | 0.001 | 0.76 |
IL2SRA(0 h) | − 0.006 | 0.002 |
0.02
| 0.002 | 0.001 | 0.09 |
Adiponectin (0 h) | − 0.003 | 0.004 | 0.46 | − 0.003 | 0.002 | 0.24 |
TNFα (0 h) | − 0.0008 | 0.003 | 0.80 | 0.007 | 0.002 |
0.0001
|
- Since the models include a quadratic term the effect of a one unit change in x on y is not constant
- EEAA extrinsic epigenetic age acceleration, 0Â h fasting time point, 6Â h postprandial time point, CRP C-reactive protein, HDL high-density lipoprotein, IL2SRA interleukin-2 soluble receptor alpha, IL6 interleukin-6, LDL low-density lipoprotein, MCP1 monocyte chemotactic protein 1, SE standard error, TC total cholesterol, TG triglyceride, TNFa tumor necrosis factor alpha
- *Model is adjusted for adjusted for age, study site, sex, fasting lipid level (if applicable), estimated T cell type percentages, epigenetic age acceleration estimate squared (i.e., a quadratic polynomial), current smoking status, current drinking status, and a random effect of family relationship
- #Model is adjusted for adjusted for age, study site, sex, fasting lipid level (if applicable), epigenetic age acceleration estimate squared (i.e., a quadratic polynomial), current smoking status, current drinking status, and a random effect of family relationship