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Table 1 Summary of percent DNA methylation at each CpG site for DNA extracted from total leukocytes (cohort 1) and CD4+ cells and saliva (cohort 2)

From: Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes

CpG site

Cohort 1 (N = 89)

Cohort 2 (N = 32)

Total leukocytes

CD4+

Saliva

    

# Missing

 

FADS1 promoter

chr11:61584836

4.93 ± 0.90

7.61 ± 1.53α*

N = 7

8.59 ± 2.17*

chr11:61584894

11.48 ± 2.39

39.66 ± 4.33*

N = 7

25.84 ± 10.74*

Putative enhancer region

chr11:61587979 (cg27386326)

81.22 ± 7.84

68.71 ± 24.20α*

N = 2

53.94 ± 15.67*

FADS2 promoter

chr11:61594865

11.80 ± 4.21

30.90 ± 9.33α*

N = 6

23.41 ± 8.26*

chr11:61594876

12.46 ± 4.51

34.82 ± 9.33α*

N = 6

23.94 ± 9.12*

chr11:61594907

12.71 ± 4.93

38.60 ± 12.89α*

N = 2

16.86 ± 7.18*

  1. Means ± standard deviations are reported. The number missing in CD4+ cells are a result of insufficient DNA volume for pyrosequencing. DNA methylation levels measured in cohort 2 (i.e., CD4+ and saliva) were significantly different compared to DNA methylation derived from leukocytes in cohort 1, as indicated by asterisks (p < 0.05). Significant differences between matched saliva and CD4+ samples in cohort 2 are denoted by α
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Clinical Epigenetics

ISSN: 1868-7083

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