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Table 2 Distribution of histone H3K18 and K14 acetylation and p300 in ccRCC tumor versus paired normal kidney according to tumor grade and stage [32, 41]

From: KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2

  Normal kidney ccRCC T vsN ccRCC G 1 ccRCC G ≥ 2 G1 vs G ≥ 2 ccRcc stage 1 ccRCC stage ≥ 2 Stage 1 vs stage ≥ 2
H3AcK14% mean ± SD 38.54 ± 29.33 34.26 ± 30.86 0.319 58.50 ± 24.605 24.56 ± 27.753 0.000 39.59 ± 32.583 24.04 ± 24.775 0.051
 Male 38.91 ± 32.31 34.85 ± 30.34 0.52       
 Female 37.83 ± 23.36 33.13 ± 32.45 0.65       
 M vs F 0.796 0.715        
H3AcK18% mean ± SD 77.02 ± 19.99 68.51 ± 25.57 0.26 48.65 ± 22.335 76.46 ± 22.403 0.000 68.76 ± 25.848 68.04 ± 25.578 0.945
 Male 75.83 ± 22.91 66.91 ± 27.03 0.12       
 Female 71.58 ± 22.74 71.58 ± 22.74 0.14       
 M vs F 0.939 0.546        
p300% mean ± SD 70.46 ± 23.46 67.73 ± 21.17 0.21 46.65 ± 17.388 76.16 ± 16.133 0.000 66.35 ± 22.584 70.38 ± 18.332 0.527
 Male 65.67 ± 20.32 72.67 ± 23.82 0.13       
 Female 71.67 ± 22.63 66.29 ± 22.66 0.41       
 M vs F 0.166 0.189