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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Pharmacological inhibition of EZH2 disrupts the female germline epigenome

Fig. 6

Tazemetostat depleted H3K27me3 in primary oocytes. Confocal images of H3K27me3 (red) and DAPI (blue) immunofluorescence in sections of E18.5 mouse ovaries cultured for 7 days with either DMSO (top panel) or 5 μM tazemetostat (bottom panel; 10 μm scale bars). Graphical representation of mean H3K27me3 staining intensity in DMSO treatment in green and tazemetostat treatment in blue, analysed by ROI manager, ImageJ. P < 0.005, Student’s t test; DMSO n = 4 and tazemetostat n = 3 biological replicates, three primary oocytes analysed per replicate. Error bars ± SEM

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