Identification of reliable biomarkers of human papillomavirus 16 methylation in cervical lesions based on integration status using high-resolution melting analysis

Table 4 The relationship between clinicopathological characteristic of three groups and HPV integrations

Variable	No. of patients	HPV integrations				P value
		Negative		Positive
		No.	%	No.	%
SCC patients
Age
< 40	6	0	0	6	100	0.99
40–50	32	2	6.25	30	93.8
> 50	12	1	8.33	11	91.7
Stage
Stage I	13	0	0	13	100	0.558
Stage II+	37	3	8.1	34	91.9	0.558
Metastasis
Negative	42	2	4.76	40	95.2	0.414
Positive	8	1	12.5	7	87.5	0.414
Number of pregnancies
< 3	21	1	4.76	20	95.2	0.99
≥ 3	25	2	8	23	92	0.99
Number of abortions
< 2	22	3	13.6	19	86.3	0.079
≥ 2	28	0	0	28	100	0.079
HSIL and LSIL patients
HSIL	30	4	13.3	26	86.7	0.017
LSIL	35	14	40	0.6	60	0.017
Age
< 40	52	7	13.5	45	86.5	0.19
40–50	11	4	36.4	7	63.6
> 50	2	0	0	2	100

This table shows both the clinicopathological characteristic of SCC, HSIL, and LSIL and their frequency of HPV integrations. P < 0.05 is considered to be significantly different

ISSN: 1868-7083