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Table 4 Univariate and multivariate Cox regression analysis for miR-122-5p and miR-206 serum levels with progression-free survival as endpoint

From: Serum miR-122-5p and miR-206 expression: non-invasive prognostic biomarkers for renal cell carcinoma

 

Univariate Analysis

Model 1

Model 2

Model 3

Model 4

HR

(95% CI)

p value

HR

(95% CI)

p value

HR

(95% CI)

p value

HR

(95% CI)

p value

HR

(95% CI)

p value

miR-122-5p, >cut-off vs. <cut-off

3.63

1.42–9.32

0.007

2.11

0.73–6.11

0.169

   

2.34

0.77–7.11

0.132

1.62

0.45–5.84

0.455

miR-206, >cut-off vs. <cut-off

4.98

1.95–12.7

< 0.001

3.67

1.29–10.51

0.015

3.46

1.13–10.68

0.030

   

2.94

0.86–10.04

0.084

pT-stage, pT3–4 vs. pT1–2

4.14

1.59–10.79

0.004

   

1.85

0.58–5.92

0.300

2.68

0.88–8.21

0.082

1.94

0.60–6.29

0.269

pN-stage, pN1 vs. pN0

6.85

1.45–32.47

0.015

   

4.01

0.68–23.72

0.125

2.72

0.49–15.11

0.252

4.40

0.72–27.01

0.109

M-stage, cM1 vs. cM0

3.61

1.25–10.42

0.018

   

1.49

0.44–5.01

0.521

1.18

0.34–3.88

0.787

1.40

0.42–4.72

0.583

Fuhrman-Grading, G3 + 4 vs. G1 + 2

4.08

1.58–10.55

0.004

   

1.48

0.43–5.18

0.536

1.65

0.48–5.67

0.426

1.18

0.29–4.86

0.816

  1. Number of patients in analysis - 67, number of events (progression) - 18