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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Serum miR-122-5p and miR-206 expression: non-invasive prognostic biomarkers for renal cell carcinoma

Fig. 1

Validation of serum miRNA expression. (ac) Serum miRNA expression levels (2-ΔΔCq) were decreased in ccRCC patients compared to healthy individuals for miR-122-5p (a) and miR-206 (c). Serum miR-193a-5p levels (b) were similar in all three subgroups. Red line implies the median value of the expression. df Receiver operator curve (ROC) analyses demonstrate that miR-122-5p and miR-206, as well as combination of both in model allowed discrimination of ccRCC and healthy controls (d). Simultaneous analysis of both miRNAs as integral parameter does not allow for better discrimination (d, e), showing the superiority of miR-206 under miR-193a-5p in terms of discrimination (miR-193a-5p does not provide any additional discriminative capability to that of miR-206). AUC – area under curve with 95% confidence intervals (also outlined as blue space along the ROC-curve). In (e, f) cross-figure means the best threshold in terms of specificity and sensitivity

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