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Table 1 Clinical and functional characteristics of the study patients

From: Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions

Anthropometric variables

Lung cancer N = 20

Lung cancer-COPD N = 20

Age, years

64 (12)

65 (9)

Male, N/female, N

13/7

20/0

BMI, kg/m2

26 (5)

26 (5)

Smoking history

 Current: N, %

12, 60

14, 70

 Ex-smoker: N, %

5, 25

6, 30

 Never smoker: N,%

3, 15

0, 0

 Pack-years

53 (25)

57 (20)

Lung function testing

 vFEV1, % pred

92 (8)

61 (14)¶¶¶

 FEV1/FVC, % pred

77 (6)

60 (8)¶¶¶

 DLCO, % pred

88 (12)

72 (21)¶¶¶

 KCO, % pred

88 (11)

73 (17)¶¶¶

TNM staging

 Stage IA: N, %

5, 25

5, 25

 Stage IB: N, %

0, 0

4, 20

 Stage IIA: N, %

1, 5

6, 30

 Stage IIB: N, %

4, 20

2, 10

 Stage IIIA: N, %

3, 15

3, 15

 Stage IIIB: N, %

4, 20

0, 0

 Stage IV: N, %

3, 15

0, 0

Histological diagnosis

 Squamous cell carcinoma: N, %

6, 30

5, 25

 Adenocarcinoma: N, %

11, 55

14, 70

 Others: N, %

3, 15

1, 5

Blood parameters

 Total leucocytes/μL

8.3 103 (1.9 103)

9.2 103 (2.1 103)

 Total neutrophils/μL

5.7 103 (2.1 103)

6.3 103 (1.7 103)

 Total lymphocytes/μL

1.7 103 (650)

2.1·103 (617)

 Albumin (g/dL)

4.4 (0.4)

4.0 (0.5)¶¶

 Total proteins (g/dL)

7.4 (0.5)

7.1 (0.6)

 Fibrinogen (mg/dL)

485 (99)

409 (77)¶¶

 CRP (mg/dL)

1.1 (1.1)

1.7 (1.2)

 GSV (mm/h)

20 (7.4)

30 (16.8)

 Ceruloplasmin (g/dL)

26.2 (4.8)

26.5 (4.8)

Body weight loss, kg

 0, N, %

18, 90

17, 85

 1–4, N, %

2, 10

1, 5

 5–8, N, %

0, 0

2, 10

 9–12, N, %

0, 0

0, 0

  1. Continuous variables are presented as mean (standard deviation), while categorical variables are presented as the number of patients in each group and percentage of the total population
  2. Abbreviations: N number, kg kilograms, m meters, BMI body mass index, FEV 1 forced expiratory volume in the first second, pred predicted, FVC forced vital capacity, DLco, carbon monoxide transfer, K CO Krogh transfer factor, TNM tumor, nodes, metastasis, CRP C-reactive protein, GSV globular sedimentation velocity, L liter
  3. p < 0.05, ¶¶p < 0.01, ¶¶¶p < 0.001 between LC-COPD and LC patients. Comparisons of the clinical and physiological variables between LC-COPD and LC patients were assessed using the Student’s t test. Differences between the study groups in the qualitative variables were assessed using the chi-square test