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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Promoter methylation inhibits expression of tumor suppressor KIBRA in human clear cell renal cell carcinoma

Fig. 2

KIBRA “CCGG” methylation within CpG I in ccRCC samples. a Methylation patterns of “CCGG”-motifs within CpG I in control (Ctrl) and ccRCC samples. Each line represents one “CCGG”-motif within CpG I. Filled circles indicate methylated, open circles indicate unmethylated “CCGG”-motifs. Differences of methylation between the control (12/144 [8.3%]) and ccRCC (14/72 [19.4%]) group were significant (p = 0.039). Analysis revealed significantly decreased mRNA KIBRA expression levels for ccRCC samples in b real-time PCR and c western blot analyses. ***p < 0.001; m median

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Clinical Epigenetics

ISSN: 1868-7083

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