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Table 2 DNA methylation in specific CpG sites

From: High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans

Genes

CpG site

Men (n = 77)

Women (n = 172)

Total (n = 249)

LINE-1

1

86.2 (84.5–86.9)

85.75 (84.5–86.9)

85.8 (84.8–86.7)

2

82.6 (82.3–82.8)

82.5 (82.2–82.8)

82.5 (82.3–82.7)

3

80.875 (80.4–81.75)

80.9 (80.3–81.3)

80.9 (80.5–81.2)

4

82.2 (81.3–83.2)

82.0 (81.6–82.4)

82.0 (81.7–82.4)

Average

83.3 (82.8–83.8)

82.8 (82.6–83.3)

82.9 (82.65–83.4)

p16

1

3.36 (3.0–3.89)

3.46 (3.25–3.64)

3.44 (3.25–3.6)

2

1.575 (1.16–1.9)

1.58 (1.45–1.87)

1.58 (1.46–1.79)

3

1.88 (1.37–2.12)

1.84 (1.62–2.07)

1.85 (1.66–2.04)

4*

2.2 (1.91–2.25)

1.88 (1.75–2.05)

1.96 (1.82–2.11)

5

0.91 (0–1.60)

1.65 (1.41–1.92)

1.49 (1.34–1.77)

6

0

0

0

7

1.89 (1.38–2.23)

1.94 (1.73–2.12)

1.91 (1.71–2.09)

Average

1.89 (1.66–2.06)

1.92 (1.78–2.02)

1.907 (1.79–2.01)

MLH1

1

0 (0–0.99)

0

0

2

1.39 (0–2.35)

1.82 (0–2.10)

1.725 (0–2.07)

3

0

0

0

4γ

2.3 (1.75–2.80)

2.495 (1.96–2.84)

2.435 (1.97–2.77)

Average

1.25 (0.70–1.38)

1.12 (0.74–1.31)

1.165 (0.81–1.31)

MGMT

1

3.345 (2.53–4.21)

4.01 (3.51–4.66)

3.8 (3.41–4.26)

2

0 (0–1.65)

0 (0–1.88)

0

3

0

0

0

4

1.865 (1.38–2.31)

1.87 (1.61–2.26)

1.87 (1.61–2.15)

5

0

0

0

6

0

0

0

Average

1.555 (1.10–2.11)

1.72 (1.39–1.87)

1.66 (1.44–1.87)

  1. Results are expressed as percentages of methylation and 95% CI. Two-sample Wilcoxon rank-sum test *p = 0.04; γ p = 0.07; for other results p > 0.1