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Fig. 2 | Clinical Epigenetics

Fig. 2

From: PAT-H-MS coupled with laser microdissection to study histone post-translational modifications in selected cell populations from pathology samples

Fig. 2

PAT-H-MS coupled with manual macrodissection. a H&E staining of mouse brains bearing glioblastoma xenografts (x). Scale bar = 2 mm. b Number of sections and histone octamer yields for the samples shown in a (samples 1–3) and d (sample 4). c Heatmap display and nonsupervised clustering of the log2 of ratios for the indicated hPTMs for macrodissected mouse brains and xenografts from samples 1–3. L/H relative abundances ratios, obtained with the super-SILAC strategy (light channel: breast cancer biopsy, heavy channel: spike-in super-SILAC standard) normalized over the average value across the samples are shown (d) H&E staining of a mouse brain bearing a glioblastoma xenografts (x) of reduced size

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