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Table 2 Distribution of socio-demographic and clinical features in 9 OPSCC patients who recurred within 24 months from end of treatment (cases) and 24 OPSCC patients who did not (controls) who served as validation set

From: Prognostic significance of LINE-1 hypomethylation in oropharyngeal squamous cell carcinoma

Variable Cases, n = 9 Controls, n = 24 p valuec
n (%) n (%)
Gender
 Male 4 (44.4) 17 (70.8) 0.23
 Female 5 (55.6) 7 (29.2)  
Age, years
 <55 1 (11.1) 4 (16.7) 1.00
 55–59 2 (22.2) 4 (16.7)  
 ≥60 6 (66.7) 16 (66.7)  
Smoking habits
 Never 3 (33.3) 5 (20.8) 0.32
 Former 1 (11.1) 1 (4.2)  
 Current 5 (55.6) 18 (75.0)  
Na, b
 0–1 3 (33.3) 9 (37.5) 1.00
 2–3 6 (66.7) 15 (62.5)  
Ta, b
 1–2 3 (33.3) 8 (33.3) 1.00
 3–4 6 (66.7) 16 (66.7)  
Stage
 III 2 (22.2) 6 (25.0) 1.00
 IV 7 (77.8) 18 (75.0)  
HPV16
 Negative 8 (88.9) 12 (50.0) 0.06
 Positive 1 (11.1) 12 (50.0)  
Therapy
 RT ± CT 3 (33.3) 12 (50.0) 0.46
 RT + CH ± CT 6 (66.7) 12 (50.0)  
  1. aThe sum does not add up to total because of missing values
  2. b N number of lymph nodes involved, T tumor size, RT radiotherapy, CT chemotherapy, CH surgery
  3. cFisher’s exact test
  4. dStatistical comparison of the different characteristics in discovery and validation series