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Table 1 Distribution of socio-demographic and clinical features, odds ratio (OR) of relapse, and corresponding 95% confidence intervals (CI) in 28 OPSCC patients who recurred within 24 months from end of treatment (cases) and 49 OPSCC patients who did not (controls)

From: Prognostic significance of LINE-1 hypomethylation in oropharyngeal squamous cell carcinoma

Variables Cases, n = 28 Controls, n = 49 OR (95% CI)a OR (95% CI)b
n (%) n (%)
Gender
 Male 19 (67.9) 33 (67.4) 1f 1f
 Female 9 (32.1) 16 (32.7) 1.07 (0.38–2.97) 1.08 (0.37–3.18)
Age (years)
 <55 10 (35.7) 18 (36.7) 1f 1f
 55–59 10 (35.7) 12 (24.5) 1.52 (0.47–4.91) 1.66 (0.49–5.66)
 ≥60 8 (28.6) 19 (38.8) 0.76 (0.25–2.37) 0.90 (0.27–3.00)
Smoking habits
 Never 4 (14.3) 10 (20.4) 1f 1f
 Former 3 (10.7) 11 (22.5) 0.62 (0.11–3.62) 0.66 (0.11–4.12)
 Current 21 (75.0) 28 (57.1) 1.73 (0.46–6.54) 1.44 (0.32–6.45)
Nc, d
 0–1 5 (17.9) 15 (31.3) 1f 1f
 2–3 23 (82.1) 33 (68.7) 2.02 (0.63–6.55) 1.12 (0.42–2.99)
Tc, d
 1–2 11 (39.3) 31 (64.6) 1f 1f
 3–4 17 (60.7) 17 (35.4) 3.23 (1.18–8.86) 1.92 (1.02–3.62)
Stage
 III 4 (13.8) 12 (25.0) 1f 1f
 IV 25 (86.2) 36 (75.0) 2.77 (0.68–11.30) 2.44 (0.58–10.29)
HPV16
 Negative 23 (82.1) 36 (73.5) 1f 1e
 Positive 5 (17.9) 13 (26.5) 0.59 (0.18–1.93) 0.92 (0.24–3.61)
Therapyc
 RT ± CT 16 (57.1) 21 (42.9) 1f 1f
 RT + CH ± CT 12 (42.9) 28 (57.1) 0.53 (0.20–1.45) 0.48 (0.16–1.51)
LINE-1 methylation
 ≥70% 6 (21.4) 19 (38.8) 1f 1f
 50 to <70% 9 (32.1) 17 (34.7) 1.68 (0.48–5.83) 2.18 (0.53–8.97)
 <50% 13 (46.4) 13 (26.5) 3.51 (1.03–12.00) 4.12 (1.01–16.91)
Continuous 10% decreasee 1.45 (1.13–1.87) 1.50 (1.13–2.00)
  1. aEstimated through logistic regression model adjusted for sex and age
  2. bAs footnote a, plus adjustment for smoking habits, stage, and HPV16
  3. c N number of lymph nodes involved, T tumor size, RT radiotherapy, CT chemotherapy, CH surgery
  4. dThe sum does not add up to total because of missing values
  5. eLINE-1 methylation analyzed as continuous variable, risk associated with 10% decrease in methylation
  6. fReference category