| Patients with PCNVs in this study | Previous reports | P value | ||||||
---|---|---|---|---|---|---|---|---|---|
 | SRS-compatible | SRS-like | Total | H19-hypo | UPD(7)mat | PCNV vs. H19-hypo | PCNV vs. UPD(7)mat | ||
SGAa | 3/3 (100%) | 2/2 (100%) | 5/5 (100%) | 43/43 (100%) | ・・・ | 9/9 (100%) | ・・・ | 1.0000 | 1.0000 |
Postnatal growth failureb, c | 2/2 (100%) | 2/2 (100%) | 4/4 (100%) | 29/35 (83%) | ・・・ | 8/9 (89%) | ・・・ | 0.6020 | 1.0000 |
Relative macrocephaly at birthd | 1/3 (33%) | 2/2 (100%) | 3/5 (60%) | 29/29 (100%) | ・・・ | 7/9 (78%) | ・・・ | 0.0178 | 0.5804 |
Protruding forehead | 3/3 (100%) | 0/2 (0%) | 3/5 (60%) | 31/37 (84%) | ・・・ | 7/9 (78%) | ・・・ | 0.2368 | 0.5804 |
Body asymmetry | 1/3 (33%) | 0/2 (0%) | 1/5 (20%) | 30/37 (81%) | ・・・ | 3/9 (33%) | ・・・ | 0.0126 | 1.0000 |
Feeding difficulties and/or low BMI | 3/3 (100%) | 0/2 (0%) | 3/5 (60%) | 16/34 (47%) | ・・・ | 6/9 (67%) | ・・・ | 0.6614 | 1.0000 |
Congenital heart disease | 2/3 (67%) | 0/2 (0%) | 2/5 (40%) | ・・・ | 8/145 (6%)e | ・・・ | 0/17 (0%)e | 0.0361 | 0.0433 |
Motor developmental delay | 2/3 (67%) | 2/2 (100%) | 4/5 (80%) | 18/37 (49%)e | ・・・ | 6/9 (67%)e | ・・・ | 0.3465 | 1.0000 |
Speech delay | 3/3 (100%) | 2/2 (100%) | 5/5 (100%) | 8/31 (26%)e | ・・・ | 6/9 (67%)e | ・・・ | 0.0034 | 0.2582 |
Reference | Â | Â | Â | Fuke T, et al. [9] | Ghanim M, et al. [29] | Fuke T, et al. [9] | Ghanim M, et al. [29] | Â | Â |