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Table 3 Clinical variables of interest and CIMP concordance status

From: The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases

Variable Metastasis − primary− (n = 64) Metastasis − primary+ (n = 1) Metastasis + primary− (n = 0) Metastasis + primary+ (n = 5) *P value
N % N % N % N %  
Age          0.52
 Mean (range) 61.0 [24.2, 79.9] 74.4 [74.4, 74.4]    60.6 [51.1, 66.8]  
 Missing 8   0   0   0   
Sex          0.36
 Female 30 50% 1 100%    1 20%  
 Male 30 50% 0 0    4 80%  
 Missing 4   0   0   0   
Stage at diagnosis          >0.99
 I 0 0 0 0    0 0  
 II 6 11% 0 0    0 0  
 III 13 23% 0 0    1 20%  
 IV 37 67% 1 100%    4 80%  
 Missing 7   0   0   0   
Primary site          >0.99
 Right 12 21% 0 0    1 20%  
 Left 45 79% 1 100%    4 80%  
 Missing 7   0   0   0   
Histological grade          0.21
 Grade 1–2 35 66% 1 100%    5 100%  
 Grade 3 18 34% 0 0    0 0  
 Missing 11   0   0   0   
Mucinous features          0.10
 No 45 82% 1 100%    2 40%  
 Yes 10 18% 0 0    3 60%  
 Missing 9   0   0   0   
Lymphovascular invasion          >0.99
 No 38 72% 1 100%    4 80%  
 Yes 15 28% 0 0    1 20%  
 Missing 11   0   0   0   
Perineural invasion          >0.99
 No 40 71% 1 100%    4 80%  
 Yes 12 21% 0 0    1 20%  
 Not applicable 4 7% 0 0    0 0  
 Missing 8   0   0   0   
Molecular status, mutant          
KRAS 22 37% 1 100% 0   1 20% 0.33
BRAF 2 3% 0 0 0   0 0 >0.99
NRAS 2 3% 0 0 0   0 0 >0.99
Mismatch repair status, deficienta    0 0 0   0 0 n/a
  1. *P values for categorical variables calculated with a Fisher’s exact test. P values for continuous variables calculated with an ANOVA
  2. aMismatch repair status was performed for cases with detected CIMP positivity in the primary and/or metastatic tissue