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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Integrated data analysis reveals potential drivers and pathways disrupted by DNA methylation in papillary thyroid carcinomas

Fig. 3

Methylation and gene expression profiling in PTC. a Genes identified in the integrative analysis with negative correlation and confirmed in the TCGA data. The outermost circle displays the human autosomal chromosomes, and the inner layers show both expression and methylation profiles. The figure was created following the parameters available in http://circos.ca. Unsupervised hierarchical clustering analysis revealed the b methylation and c gene expression profiles of 34 PTC evaluated with both platforms, and the relation with histological variant, genetic alteration, and follow-up. Two clusters were identified by both methodologies, and an overlapping between methylation and expression data was observed (dark and gray clustering). Gray cluster of methylation and gene expression was associated with a higher frequency of BRAF-mutated tumors (p = 0.034 and p = 0.013, respectively; Fisher’s exact test)

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