Skip to main content

Table 4 Top10 CpG sites by biomarker ranking that differentiate subcutaneous and omental adipose tissue at each time point

From: Genome-wide DNA methylation analysis reveals loci that distinguish different types of adipose tissue in obese individuals

Illumina probe ID

AB mean beta (±standard deviation)

OM mean beta (±standard deviation)

UCSC gene namea b

CpG site chromosome and positionb

Traditional analysis rank by P value

Traditional analysis rank by absolute Δbeta

Before weight loss analysis

 cg02245004

0.12 (±0.08)

0.64 (±0.11)

Intergenic

15:76634887

318

1

 cg03923561

0.45 (±0.07)

0.04 (±0.02)

HOXC4

12:54447220

12

5

 cg22747076

0.42 (±0.09

0.02 (±0.02)

HOXC4

12:54447873

31

7

 cg09400037

0.42 (±0.06)

0.82 (±0.07)

Intergenic

16:84822801

102

6

 cg24376776

0.03 (±0.01)

0.33 (±0.03)

Intergenic

10:101297245

1

62

 cg11797364

0.59 (±0.1)

0.97 (±0.02)

Intergenic

6:436969

329

14

 cg17496661

0.65 (±0.08)

0.99 (±0.01)

Intergenic

5:3326343

146

28

 cg09720701

0.37 (±0.05)

0.06 (±0.01)

HOXC4

12:54447283

7

47

 cg02264990

0.35 (±0.06)

0.03 (±0.02)

HOXC4

12:54447243

30

46

 cg01524853

0.43 (±0.05)

0.12 (±0.03)

HOXC4

12:54447807

2

51

After weight loss analysis

 cg00838040

0.34 (±0.07)

0.97 (±0.03)

ATP2C2

16:84446919

2

1

 cg21917524

0.31 (±0.07)

0.81 (±0.04)

Intergenic

11:74200334

19

10

 cg24145118

0.84 (±0.07)

0.31 (±0.16)

Intergenic

10:2777041

3554

7

 cg12984729

0.09 (±0.03)

0.59 (±0.16)

ISL2

15:76633817

3338

11

 cg12437821

0.46 (±0.04)

0.05 (±0.09)

Intergenic

12:114852027

185

48

 cg01184975

0.53 (±0.05)

0.10 (±0.11)

Intergenic

12:114852091

567

33

 cg20291855

0.03 (±0.03)

0.44 (±0.11)

Intergenic

4:13524143

1994

42

 cg25365014

0.79 (±0.05)

0.41 (±0.05)

Intergenic

5:2727713

1

89

 cg16297011

0.07 (±0.04)

0.48 (±0.11)

Intergenic

4:13539023

1771

40

 cg21982455

0.56 (±0.04)

0.19 (±0.07)

Intergenic

5:2757976

92

86

  1. a‘Intergenic’, no gene loci annotation in Illumina manifest
  2. bGene symbol and map position as Illumina manifest, GRCh37/hg19