Model | Matched sample | BLITZ population |
---|
Screening setting | | |
Risk-factors-only model | 0.43 (0.29,0.55) | 0.68 (0.57,0.76) |
Markers-only model | 0.69 (0.55,0.82) | 0.74 (0.57,0.87) |
Full model | 0.69 (0.54,0.83) | 0.76 (0.61,0.87) |
Clinical setting | | |
Risk-factors-only model | 0.45 (0.35,0.54) | 0.74 (0.70,0.77) |
Markers-only model | 0.73 (0.63,0.83) | 0.78 (0.66,0.88) |
Full model | 0.73 (0.61,0.82) | 0.81 (0.71,0.88) |
- Mean and 95% confidence intervals of c-statistics. Values for “BLITZ population” represent a weighting of participants from the matched sample to achieve similar distribution of risk factors as in the BLITZ population. The three models are: (i) risk-factors-only model including sex and age; (ii) markers-only model, including methylation levels of the three identified biomarkers; and (iii) full model, combining both risk factors and markers