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Table 3 Associations of PITX2 DNA methylation (mPITX2) with clinicopathological parameters of PCa patients from the training cohort (n = 498)
| Patients (n) | Median mPITX2 (%) | mPITX2 low | mPITX2 high | p value | |
|---|---|---|---|---|---|
| All patients | 498 (100 %) | 32.9 | |||
| Mean/median follow-up (months) | 22/16 | ||||
| Age (years) | 0.001a | ||||
| ≤60 | 224 (45.0 %) | 31.0 | 128 (57.1 %) | 96 (42.9 %) | |
| >60 | 274 (55.0 %) | 35.2 | 135 (49.1 %) | 140 (50.9 %) | |
| Unknown | 0 (0.0 %) | ||||
| T category | 0.043a | ||||
| pT1/2 | 188 (37.8 %) | 25.7 | 137 (70.3 %) | 58 (29.7 %) | |
| pT3/4 | 293 (58.8 %) | 37.5 | 126 (41.4 %) | 178 (58.6 %) | |
| Unknown | 17 (3.4 %) | ||||
| ISUP Gleason grading group | <0.001b | ||||
| 1 (<7) | 45 (9 %) | 28.0 | 31 (68.9 %) | 14 (31.1 %) | |
| 2 (3 + 4) | 147 (29.5 %) | 28.6 | 95 (64.2 %) | 53 (35.8 %) | |
| 3 (4 + 3) | 101 (20.3 %) | 31.5 | 55 (54.5 %) | 46 (45.5 %) | |
| 4 (=8) | 64 (12.9 %) | 34.1 | 33 (51.6 %) | 31 (48.4 %) | |
| 5 (>8) | 141 (28.3 %) | 41.0 | 49 (34.8 %) | 92 (65.2 %) | |
| Unknown | 0 (0.0 %) | ||||
| Surgical margin | <0.001a | ||||
| R0 | 318 (63.9 %) | 30.8 | 180 (56.8 %) | 137 (43.2 %) | |
| R1 | 152 (30.5 %) | 37.0 | 68 (44.7 %) | 84 (55.3 %) | |
| Unknown | 28 (5.6 %) | ||||
| Nodal status | 0.19a | ||||
| pN0 | 349 (70.1 %) | 32.3 | 184 (53.0 %) | 163 (47.0 %) | |
| pN1 | 79 (15.8 %) | 36.6 | 32 (40.5 %) | 47 (49.5 %) | |
| Unknown | 70 (14.1 %) | ||||
| Pre-surgical PSA (ng/ml) | 0.36b | ||||
| 0–4 | 53 (10.6 %) | 29.5 | 31 (58.5 %) | 122 (41.5 %) | |
| 4–10 | 286 (57.5 %) | 32.9 | 150 (52.4 %) | 136 (47.6 %) | |
| >10 | 156 (31.3 %) | 34.3 | 79 (50.3 %) | 78 (49.7 %) | |
| Unknown | 3 (0.6 %) | ||||
| ERG fusionc | <0.001a | ||||
| Negative | 178 (35.8 %) | 28.0 | 122 (62.9 %) | 66 (37.1 %) | |
| Positive | 152 (30.5 %) | 37.2 | 69 (45.4 %) | 83 (54.6 %) | |
| Unknown | 168 (33.7 %) | ||||
| AR score | 0.15a | ||||
| Negative | 246 (49.4 %) | 30.6 | 140 (56.9 %) | 106 (43.1 %) | |
| Positive | 84 (16.9 %) | 34.6 | 41 (48.8 %) | 43 (51.2 %) | |
| Unknown | 186 (33.7 %) |
