Skip to main content

Advertisement

Table 4 CpGs differentially methylated in relation to smoking status also related to quantitative measures of smoking (p correlation <0.05, ordered by chromosomal location)

From: DNA methylation and smoking in Korean adults: epigenome-wide association study

Chra Gene Distance to geneb Probe Epigenome-wide association study ρd Pρ
Coefc p
Urine cotinine in current smokers (N = 31)
 1 GNG12   cg25189904e,f −0.134 1.4E−06 −0.40 0.027
 3 GPR15   cg19859270e,f −0.027 1.0E−07 −0.56 0.001
 4 MTNR1A   cg22261866 −0.063 1.6E−06 0.37 0.041
 5 AHRR   cg05575921e,f −0.203 6.5E−13 −0.43 0.016
 15 FAM82A2   cg19440278 0.007 7.0E−06 −0.43 0.016
 19 F2RL3   cg03636183e,f −0.128 2.0E−08 −0.56 0.001
Pack-year in current smokers (N = 31)
 1 NT5C1A   cg00990022 −0.04 5.5E−06 0.39 0.036
 6 ZBTB9   cg03945003 −0.023 3.9E−06 0.40 0.031
 10 JAKMIP3   cg19134728e −0.023 1.2E−05 0.37 0.045
 11 HPX   cg25426350 −0.03 2.5E−06 0.44 0.016
 11 CCND1   cg09520904 −0.036 7.5E−07 −0.44 0.015
 21 RNF160   cg13662262 −0.01 9.2E−06 0.44 0.015
Time since quit smoking in former smokers (N = 30)
 1 IFI16 −9970 cg19707735 −0.035 1.0E−04 0.47 0.009
 2 CLASP1   cg22346073 −0.052 8.0E−07 0.43 0.017
 3 ARHGEF3   cg25799109e −0.076 4.4E−05 −0.44 0.016
 3 KTELC1   cg16958524 −0.029 6.9E−06 0.39 0.033
 5 SPEF2   cg08534016 −0.050 0.001 0.42 0.021
 6 ACOT13 16438 cg09447457 −0.010 1.2E−05 0.39 0.034
 9 BSPRY   cg02003202 −0.049 9.5E−06 0.44 0.015
 15 FAM82A2   cg21580007 −0.049 9.0E−04 0.47 0.009
  1. Results for current and former smokers showed regression coefficients and p values from EWAS for current and former smokers, respectively
  2. aChromosome
  3. bDistance to transcription start site of the mapped gene (basepair, based on National Center for Biotechnology Information human reference genome assembly Build 37.3)
  4. cRegression coefficient from statistical model
  5. dSpearman correlation (rho) was used for urine cotinine and pack-years in current smokers and time since quit smoking in former smokers. The methylation values were adjusted for age, sex, body mass index, chronic obstructive pulmonary disease status, and estimated cell composition
  6. eProbe identified in previous epigenome-wide association studies (EWASs) of smoking
  7. fProbe identified in one previous EWAS of serum cotinine