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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Neonatal monocytes exhibit a unique histone modification landscape

Fig. 4

Monocytes display a decrease in the enhancer mark H3K4me1 with a parallel increase in the activating mark H3K4me3 as development progresses from neonate to adult. a Total monocyte peak numbers of the histone modifications H3K4me3 (from our dataset), H3K9me3, H3K27me3, H3K4me1, H3K27ac, and H3K36me3 (from the Blueprint Consortium) in term neonatal and adult CD14+ monocytes. *p < 0.05, **p < 0.01. b Genomic location of histone modification peaks in term neonatal and adult monocytes. c Correlation heatmap comparing histone modification peak occupancy sites. T = term monocytes, A = adult monocytes. d Number of differentially bound histone modification peaks between neonatal and adult monocytes

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