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Table 1 Estimated cohort sizes for 80 % power at individual loci and genome wide in twin and case-control EWAS designs (from [93], under CC BY 4.0 licence)

From: DNA methylation: conducting the orchestra from exposure to phenotype?

Difference (%) Twin Case-control
P < 0.05 P < 1 × 10−6 P < 0.05 P < 1 × 10−6
t testa Wilcoxb t testa Wilcoxb t testc Wilcoxd t testc Wilcoxd
7 30 30 178 178 37 37 211 211
8 25 25 145 149 30 30 169 169
9 20 20 117 117 24 24 137 137
10 17 18 98 102 20 21 112 110
11 15 15 81 83 17 18 96 95
12 13 13 71 71 15 16 80 80
13 11 12 63 69 13 13 70 70
14 10 11 55 62 11 13 61 63
15 9 10 50 57 10 11 54 57
  1. a t test, paired t test
  2. bWilcox, Wilcoxon signed-rank test
  3. c t test, two-sample t test
  4. dWilcox, Wilcoxon rank-sum test