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Fig. 3 | Clinical Epigenetics

Fig. 3

From: p38-MAPK/MSK1-mediated overexpression of histone H3 serine 10 phosphorylation defines distance-dependent prognostic value of negative resection margin in gastric cancer

Fig. 3

Association of H3S10ph with the distance of negative resection margins in GC. a, c Resection margins were grouped as per their distance from the site of the tumor with 1 cm interval and mean H-score of H3S10ph immunostaining of each group was compared with tumor (left panel). In case of both PRM and DRM, analysis showed a significant decrease in H3S10ph levels as the margin length reaches more than 4 cm (left panel). Comparison of mean H-score of H3S10ph immunostaining of all resection margins with a margin distance ≤4 and >4 cm with tumor confirms the significant reduction of H3S10ph if the margin distance is >4 cm (right panel). b, d Confirmation of reduction of H3S10ph, if the margin length is >4 cm by immunoblotting. GC gastric cancer, PRM proximal resection margin, DRM distal resection margin. Statistical tests are done by using Mann-Whitney test () and Wilcoxon matched pairs test. *p < 0.05, **p < 0.01, ***p<0.001

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