Table 1 Description of two subsets of the ESTHER study, an epidemiological study of the elderly general population in Germany
From: Frailty is associated with the epigenetic clock but not with telomere length in a German cohort
Characteristic | Dataset 1 | Dataset 2 | p a | |
|---|---|---|---|---|
Total | n | 969 | 851 | |
Age in years | μ (SD) | 62.1 (6.5) | 63.0 (6.7) | 0.0078 |
Methylation age in years | μ (SD) | 61.7 (7.1) | 64.6 (7.7) | <0.0001 |
Age acceleration in yearsb | μ (SD) | −0.5 (5.0) | 1.6 (5.3) | <0.0001 |
Relative telomere length | μ (SD) | 1.22 (0.31) | 1.03 (0.27) | <0.0001 |
Frailty index (in %) | μ (SD) | 25.0 (14.7) | 25.5 (15.1) | 0.41 |
Sex | ||||
Females | n (%) | 484 (50.0) | 464 (54.5) | 0.051 |
Males | n (%) | 485 (50.1) | 387 (45.5) | |
Smoking behaviorc | ||||
Never | n (%) | 455 (48.0) | 371 (45.0) | 0.38 |
Former | n (%) | 320 (33.7) | 284 (34.5) | |
Current | n (%) | 174 (18.3) | 169 (20.5) | |
Alcohol consumptionc | ||||
None | n (%) | 300 (33.6) | 260 (33.7) | 0.76 |
<20 g/d (women), <40 g/d (men) | n (%) | 524 (58.6) | 458 (59.4) | |
20+ g/d (women), 40+ g/d (men) | n (%) | 70 (7.8) | 53 (6.9) | |
History of cancerc | ||||
Self-report negative | n (%) | 882 (93.2) | 742 (90.5) | 0.034 |
Self-report positive | n (%) | 64 (6.8) | 78 (9.5) | |