The cardiovascular and hypothalamus-pituitary-adrenal axis response to stress is controlled by glucocorticoid receptor sequence variants and promoter methylation

Table 4 Linear mixed effects models for systolic and diastolic blood pressure

	Value	SEM	DF	t value	p value
SBP
Intercept	114.154	1.701	1864	67.115	0
High methylation group	−2.362	1.344	199	−1.757	0.0083
Time	−0.375	0.099	1864	−3.758	0.0002
Arousal	−0.052	0.037	199	−1.395	0.0761
Stress	0.028	0.035	199	0.805	0.3964
Test group (seCPT vs control)	2.313	1.652	199	1.400	0.2042
DBP
Intercept	67.572	1.067	1864	63.350	0
High methylation group	−2.225	0.942	200	−2.361	0.0192
Time	−0.085	0.068	1864	−1.254	0.2101
Arousal	−0.03184	0.026	200	−1.203	0.2302
Stress	0.025	0.025	200	1.004	0.3164
Test group (seCPT vs control)	2.551	1.174	200	2.173	0.031

ISSN: 1868-7083