Fig. 5

NR3C1 promoter methylation effects on the systolic blood pressure response to the warm (control) or ice-cold water (seCPT) over the course of the experiment. Donors were split by median sum methylation levels. Systolic blood pressure in millimeter of mercury after the control (a) or cold water (b) was administered at 23 min and lasted 3 min. In both panels: filled circles, low methylation group; filled triangles, high methylation group. Data are the mean ± standard deviation. c Correlation between the mean baseline SBP and sum promoter 1F and 1H methylation levels. All participants are included, and each data point represents one participant. d Correlation between the mean baseline DBP and sum promoter 1F and 1H methylation levels. All participants are included, and each data point represents one participant. Baseline SBP and DBP mean of the three time-points immediately preceding the warm or cold water exposure