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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Insulin-like growth factor axis in pregnancies affected by fetal growth disorders

Fig. 5

Spearman’s correlation between placental promoter CpG methylation and increasing order of birthweight centiles. a IGF1 methylation vs. birthweight centiles, b IGFBP1 methylation vs. birthweight centiles, c IGFBP2 methylation vs. birthweight centiles, d IGFBP3 methylation vs. birthweight centiles, e IGFBP4 methylation vs. birthweight centiles, f IGFBP7 methylation vs. birthweight centiles. A significant negative correlation between IGF1 mRNA expression and a significant positive correlation between the binding protein expression with increasing order of birthweight centiles could reflect the indirect role played by DNA methylation relationship in controlling fetal growth by controlling gene expression of the IGF axis

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