Genome- and epigenome-wide association study of hypertriglyceridemic waist in Mexican American families

Clinical Epigenetics

Table 3 Improvement in Kullback-Leibler R ² by including CpG sites significantly associated with HTGW^a

Model	K-L R ²	∆K-L R²	P
Base^b	0.1015	-	-
Base + cg00574958	0.1284	0.0269	2.8 × 10⁻¹⁵
Base + cg00577958 + cg17058475	0.1728	0.0444	0.0302
Base + cg00574958 + cg17058475 + cg06500161	0.1967	0.0239	2.1 × 10⁻⁶

^aAnalyses show the improvement in K-L R ² statistic for a model compared to the preceding model
^bIncluded following covariates: age, age², sex, age × sex interaction, and age² × sex interaction, Illumina Sentrix® ID and Sentrix® position (to account for batch effects), use of anti-lipid, anti-hypertensive and anti-diabetic medications, and cellular heterogeneity

ISSN: 1868-7083