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Table 3 Improvement in Kullback-Leibler R 2 by including CpG sites significantly associated with HTGWa

From: Genome- and epigenome-wide association study of hypertriglyceridemic waist in Mexican American families

Model K-L R 2 ∆K-L R2 P
Baseb 0.1015 - -
Base + cg00574958 0.1284 0.0269 2.8 × 10−15
Base + cg00577958 + cg17058475 0.1728 0.0444 0.0302
Base + cg00574958 + cg17058475 + cg06500161 0.1967 0.0239 2.1 × 10−6
  1. aAnalyses show the improvement in K-L R 2 statistic for a model compared to the preceding model
  2. bIncluded following covariates: age, age2, sex, age × sex interaction, and age2 × sex interaction, Illumina Sentrix® ID and Sentrix® position (to account for batch effects), use of anti-lipid, anti-hypertensive and anti-diabetic medications, and cellular heterogeneity
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Clinical Epigenetics

ISSN: 1868-7083

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