Table 1 Top-ranked results from EWAS of 41 cancer discordant MZ twin-pairs
|  |  |  |  | Discovery EWAS N = 41 MZ twin-pairs (prior to and after diagnosis) | Replication N = 9 MZ twin-pairs (NTR replication) | Discordant vs healthy MZ pairs N = 9 vs N = 480 (NTR variability) | EWAS prior to diagnosis N = 15 MZ twin-pairs (prior to diagnosis only) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
CpG | Position (hg19) | Associated gene | Location | Rank EWAS | Mean difference* | P value | Mean difference* | P value | P value | Rank EWAS | Mean difference* | P value |
cg02444695 | Chr6:148950185 | – | – | 1 | 0.70 | 1.80 × 10−7 | −0.64 | 0.26 | 0.09 | 10 | 0.88 | 2.40 × 10−5 |
cg26079695 | Chr6:33143273 | COL11A2 | Intron | 2 | −0.67 | 3.32 × 10−6 | −050 | 0.23 | 0.34 | 1518 | −0.88 | 4.10 × 10-3 |
cg27094856 | Chr19:41732589 | AXL | Intron | 3 | 0.56 | 3.41 × 10−6 | 0.02 | 0.96 | 0.05 | 3801 | 0.51 | 9.71 × 10−3 |
cg21046959 | Chr6:22180833 | LINC00340 | Transcript | 4 | −0.53 | 8.89 × 10−6 | −0.43 | 0.37 | – | 407 | −0.73 | 1.21 × 10-3 |