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Table 1 Top-ranked results from EWAS of 41 cancer discordant MZ twin-pairs

From: Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs

     Discovery EWAS N = 41 MZ twin-pairs (prior to and after diagnosis) Replication N = 9 MZ twin-pairs (NTR replication) Discordant vs healthy MZ pairs N = 9 vs N = 480 (NTR variability) EWAS prior to diagnosis N = 15 MZ twin-pairs (prior to diagnosis only)
CpG Position (hg19) Associated gene Location Rank EWAS Mean difference* P value Mean difference* P value P value Rank EWAS Mean difference* P value
cg02444695 Chr6:148950185 1 0.70 1.80 × 10−7 −0.64 0.26 0.09 10 0.88 2.40 × 10−5
cg26079695 Chr6:33143273 COL11A2 Intron 2 −0.67 3.32 × 10−6 −050 0.23 0.34 1518 −0.88 4.10 × 10-3
cg27094856 Chr19:41732589 AXL Intron 3 0.56 3.41 × 10−6 0.02 0.96 0.05 3801 0.51 9.71 × 10−3
cg21046959 Chr6:22180833 LINC00340 Transcript 4 −0.53 8.89 × 10−6 −0.43 0.37 407 −0.73 1.21 × 10-3
  1. *The mean differences are determined using adjusted DNA methylation values and calculated as cancer − unaffected twin