Fig. 1

Diagnostic characteristics and global methylation profiles of 41 cancer-discordant MZ twin-pairs. a Number of cases for each primary location of cancer, where a blood sample was obtained before (white) and after (black) cancer diagnosis. b Dendrogram of the unadjusted global methylation profiles. Annotation bars denote each individual’s cancer status, type of cancer (identical for both twins in a pair), and family identifier (identical for both twins in a pair). c Pair-wise correlation in DNA methylation profiles shows greater similarity within MZ pairs, compared to pairs of unrelated individuals, either paired at random or at within affection status