From: The influence of menstrual cycle and endometriosis on endometrial methylome
Microarray study | Patients with endometriosis (n = 31) | Disease-free women (n = 24) | ||
---|---|---|---|---|
Estonian patients | Oxford patients | Estonian controls | Oxford controls | |
(n = 24) | (n = 7) | (n = 17) | (n = 7) | |
Age (years ± SD) | 31.0 ± 4.0 | 36.0 ± 5.0 | 30.1 ± 3.2 | 34.2 ± 6.2 |
BMI (mean, kg/m2 ± SD) | 21.8 ± 3.1 | 23.6 ± 2.0 | 23.6 ± 4.2 | 26.0 ± 4.3 |
Smoking (n) | 0 | 2 | 0 | 0 |
Stage I–II (n) | 16 | 3 | NA | NA |
Stage III–IV (n) | 8 | 4 | NA | NA |
Only endometrioma (n) | 0 | 4 | NA | NA |
Only peritoneal lesions (n) | 14 | 3 | NA | NA |
Peritoneal lesions together with endometrioma (n) | 10 | 0 | NA | NA |
Menstrual cycle characteristics | ||||
Menstrual phase (days 1–5), (n) | 0 | 4 | 0 | 1 |
Proliferative phase (days 6–14), (n) | 0 | 2 | 0 | 3 |
Early-secretory phase (days 15–20),(n) | 7 | 0 | 0 | 1 |
Mid-secretory phase (days 21–23), (n) | 8 | 1 | 17 | 0 |
Late-secretory phase (days 24–28), (n) | 9 | 0 | 0 | 2 |
Validation study | Patients with endometriosis (n = 15) | Disease-free women (n = 14) | ||
Age (years ± SD) | 31.0 ± 3.39 | 32.0 ± 2.7 | ||
BMI (mean, kg/m2 ± SD) | 20.0 ± 3.92 | 23.1 ± 5.73 | ||
Smoking (n) | 1 | 2 | ||
Mid-secretory phase (days 21–23), (n) | 7 | 7 | ||
Late-secretory phase (days 24–28), (n) | 8 | 7 | ||
Stage I–II (n) | 13 | NA | ||
Stage III–IV (n) | 2 | NA |