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Table 2 The top-20 of differentially methylated positions representing changes in DNA methylation that differ between participants receiving folic acid and vitamin B12 or placebo

From: The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects

      

Mean change in methylation (%)

CpG

Chr

Gene

Gene feature

p value

Adjusted p value

Folic acid and vitamin B12

Placebo

cg19380919

2

–

–

9.9E-08

0.0426

1.0

−1.4

cg05308617

3

ARMC8

TSS200

8.4E-07

0.1810

0.6

−0.6

cg06016645

10

NODAL

3′UTR

1.6E-06

0.2323

1.5

−0.8

cg11567849

6

REV3L

Body

2.7E-06

0.2495

0.8

−1.0

cg10367137

10

–

–

3.8E-06

0.2495

0.7

−1.1

cg18514573

6

–

–

4.0E-06

0.2495

0.6

−0.6

cg03330920

16

IFT140

Body

4.6E-06

0.2495

1.9

−2.1

cg01129246

4

GRXCR1

Body

4.9E-06

0.2495

2.6

−4.1

cg16895973

11

TOLLIP

Body

6.0E-06

0.2495

1.3

−2.6

cg09708616

6

–

–

6.3E-06

0.2495

1.4

−1.3

cg04530976

6

ZBTB9

Body

6.4E-06

0.2495

0.8

−0.9

cg27610561

20

SLC2A10

TSS1500

8.2E-06

0.2665

1.0

−1.6

cg05119686

10

–

–

8.7E-06

0.2665

1.5

−1.1

cg03761210

20

NECAB3;C20orf144

Body

8.7E-06

0.2665

0.3

−0.3

cg07292606

2

TEX261

Body

9.4E-06

0.2665

2.0

−0.9

cg27194173

10

ADK

Body

9.9E-06

0.2665

1.9

−0.9

cg06191076

1

DIRAS3

TSS200

1.3E-05

0.3192

2.7

−2.5

cg00066153

11

ACRV1

1stExon; 5′UTR

1.3E-05

0.3192

1.1

−0.9

cg20455570

7

OSBPL3

5′UTR

1.7E-05

0.3888

1.2

−1.0

cg24106824

17

MRPL12

3′UTR

2.0E-05

0.4105

1.1

−0.6

  1. Mean changes in methylation are presented as beta-values ranging from 0–100 %. The adjusted p values for the comparisons between the two groups control the false discovery rate using the Benjamini-Hochberg procedure. Abbreviations: Chr chromosome, TSS200 200 base pairs around the transcription start site, TSS1500 1500 base pairs around the transcription start site, 3′UTR 3′ untranslated region, 5′UTR 5′ untranslated region