Skip to main content


Fig. 1 | Clinical Epigenetics

Fig. 1

From: Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia

Fig. 1

Histone acetylation alters chromatin structure. Acetylation removes the positive charge on the histones with histone acetyltransferases, which is referred to as euchromatin. As a consequence, the condensed chromatin is transformed into a more relaxed structure that is associated with greater levels of gene transcription. However, this relaxation can be reversed by histone deacetylase, which is referred to as heterochromatin. Acetylation has been closely associated with increases in transcriptional activation while deacetylation has been linked with transcriptional deactivation

Back to article page