Table 1 Summary of mouse tumor studies
Treatment | Colon tumor incidence | Multiplicity (tumors/mouse) | Tumor burden (mm3) | Average food consumption (g/day) | Mouse weight at end of study (g) |
|---|---|---|---|---|---|
A 25-week study | |||||
No SFN | 23/24 (95.8 %) | 5.3 ± 2.8 | 18.4 ± 15.9 | 3.5 ± 0.8 | 45.3 ± 4.9 |
Daily SFN | 15/21 (71.4 %) | 2.8 ± 2.5* | 7.1 ± 7.2* | 3.9 ± 1.3 | 43.6 ± 3.8 |
Alt SFN | 10/11 (90.9 %) | 7.2 ± 4.4 | 22.6 ± 18.3 | 3.8 ± 1.0 | 44.0 ± 2.9 |
B 35-week study | |||||
−SFN (Nrf2+/+) | 28/28 (100 %) | 7.0 ± 3.7 | 62.7 ± 53.5 | 3.7 ± 0.7 | 51.3 ± 6.5 |
+SFN (Nrf2+/+) | 27/28 (96.4 %) | 5.7 ± 4.0 | 26.0 ± 30.2* | 3.6 ± 1.5 | 44.7 ± 7.0 |
−SFN (Nrf2−/+) | 31/32 (96.8 %) | 4.0 ± 2.1 | 14.6 ± 24.8 | 3.1 ± 0.6 | 45.2 ± 8.0 |
+SFN (Nrf2−/+) | 28/31 (90.3 %) | 3.0 ± 2.1 | 11.7 ± 13.5 | 3.2 ± 0.5 | 43.8 ± 6.5 |