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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Epigenetic synergy between decitabine and platinum derivatives

Fig. 3

Baseline gene expression and DNA methylation in YB5 cells. a. Percent DNA methylation at CpG sites within ±500 bp from TSS of 9083 genes (x-axis) vs gene expression at baseline (y-axis). b. Baseline methylation vs expression for the subset of regulated genes showing expression changes ≥1.5-fold after treatment with decitabine, carboplatin, or their combination. The broken line divides the data into four quadrants: (Q1) upper left, unmethylated expressed genes; (Q2) upper right, methylated expressed genes; (Q3) lower left, unmethylated silenced genes; and (Q4) lower right, methylated silenced genes

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