Skip to main content

Table 5 Immunohistochemical expression of D3 and FOXD2 proteins in SAC, CC and hMSI-H CRC

From: Methylome profiling reveals functions and genes which are differentially methylated in serrated compared to conventional colorectal carcinoma

   

SAC (n = 42)

CC (n = 49)

hMSI-H (n = 13)

Protein

 

n

n

%

n

%

p value

n

%

p value†

D3

distribution

A

7

16,7

8

16,3

 

0

0,0

 
  

B

8

19,0

16

32,7

0.144*

1

7,7

0.049*

  

C

27

64,3

25

51,0

0.313

12

92,3

0.132

 

intensity

1

11

26,2

22

44,9

 

7

53,8

 
  

2

12

28,6

16

32,7

0.018*

5

38,5

0.013*

  

3

19

45,2

11

22,4

0.051

1

7,7

0.039

FOXD2

distribution

A

0

0,0

6

12,2

 

7

53,8

 
  

B

6

14,3

13

26,5

0.008*

3

23,1

<0.0001*

  

C

36

85,7

30

61,2

0.013

3

23,1

<0.0001

 

intensity

1

2

4,8

2

4,1

 

11

84,6

 
  

2

17

40,5

32

65,3

0.02*

2

15,4

0.0005*

  

3

23

54,8

15

30,6

0.054

0

0,0

<0.0001

  1. SAC Serrated adenocarcinoma, CC Conventional carcinoma, hMSI-H colorectal carcinoma showing typical molecular and histological features of MSI-H
  2. *Fisher p value calculated when grouping the first two categories, i.e. A + B or 1 + 2
  3. †SAC vs. hMSI-H comparison