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Table 5 Immunohistochemical expression of D3 and FOXD2 proteins in SAC, CC and hMSI-H CRC

From: Methylome profiling reveals functions and genes which are differentially methylated in serrated compared to conventional colorectal carcinoma

    SAC (n = 42) CC (n = 49) hMSI-H (n = 13)
Protein   n n % n % p value n % p value†
D3 distribution A 7 16,7 8 16,3   0 0,0  
   B 8 19,0 16 32,7 0.144* 1 7,7 0.049*
   C 27 64,3 25 51,0 0.313 12 92,3 0.132
  intensity 1 11 26,2 22 44,9   7 53,8  
   2 12 28,6 16 32,7 0.018* 5 38,5 0.013*
   3 19 45,2 11 22,4 0.051 1 7,7 0.039
FOXD2 distribution A 0 0,0 6 12,2   7 53,8  
   B 6 14,3 13 26,5 0.008* 3 23,1 <0.0001*
   C 36 85,7 30 61,2 0.013 3 23,1 <0.0001
  intensity 1 2 4,8 2 4,1   11 84,6  
   2 17 40,5 32 65,3 0.02* 2 15,4 0.0005*
   3 23 54,8 15 30,6 0.054 0 0,0 <0.0001
  1. SAC Serrated adenocarcinoma, CC Conventional carcinoma, hMSI-H colorectal carcinoma showing typical molecular and histological features of MSI-H
  2. *Fisher p value calculated when grouping the first two categories, i.e. A + B or 1 + 2
  3. †SAC vs. hMSI-H comparison