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Table 3 Differences in percentage of methylation in FOXD2 3′ UTR for the two groups defined with each binary variable

From: Methylome profiling reveals functions and genes which are differentially methylated in serrated compared to conventional colorectal carcinoma

Variable n1 n2 Mean1 Mean2 Eequal variances Difference (1–2) gl t p values
Source 31 normal 90 tumoural 32.35 52.69 No −20.35 112 −7.094 <0.001
Nationality 98 Spanish 23 Finnish 47.62 46.89 No 0.72 29 .128 0.899
Sex 32 female 59 male 47.98 46.96 Yes 1.02 119 .262 0.794
Ma 106 0 s 12 1 s 47.38 50.69 Yes −3.31 116 −.517 0.606
KRAS 85 native 34 mutated 44.89 53.74 Yes −8.85 117 −2.095 0.038
BRAF 100 native 18 mutated 44.93 62.11 No −17.18 48 −5.247 <0.001
PI3K exon10a 90 native 5 mutated 46.91 58.55 Yes −11.65 93 −1.254 0.213
PI3K exon20a 92 native 3 mutated 46.91 66.37 No −19.47 3 −3.692 0.038
MSI 102 MSS 16 MSI 44.65 63.58 No −18.93 70 −6.887 <0.001
  1. aWhen the sample size is <15 in any of the groups, t test should not be interpreted. The Mann-Whitney’s U test was used for the variables M, PI3K exon10 and PI3K exon20. No significant differences were found for any of them