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Table 3 Logistic regression analysis of the effect of methylation level of imprinted gene DMRs on disease risk

From: Breast cancer risk and imprinting methylation in blood

Imprinted gene DMRs

Chr. 6

Chr. 11

Chr. 13

Chr. 15

Chr. 19

PLAGL1/ZAC1

H19-ICR1

IGF2-DMR2

KvDMR-ICR2

RB1

SNRPN-DMR1

PEG3

All Cases vs. Controls

0.987 [0.953,1.022] p = 0.462

1.026 [0.986,1.068] p = 0.210

1.028 [0.998,1.059] p = 0.068

1.049 [0.976,1.128] p = 0.193

1.001 [0.965,1.038] p = 0.947

0.985 [0.930,1.043] p = 0.601

1.079** [1.020,1.142] p = 0.008

IDC vs. Controls

1.002 [0.966,1.039] p = 0.932

1.030 [0.987,1.074] p = 0.171

1.025 [0.994,1.057] p = 0.123

0.993 [0.920,1.072] p = 0.860

1.006 [0.967,1.046] p = 0.772

0.991 [0.932,1.054] p = 0.932

1.065* [1.002,1.132] p = 0.042

DCIS vs. Controls

0.905* [0.833,0.982] p = 0.017

1.007 [0.932,1.088] p = 0.862

1.039 [0.984,1.099] p = 0.170

1.395*** [1.190,1.635] p < 0.001

0.976 [0.904,1.053] p = 0.530

0.954 [0.851,1.068] p = 0.412

1.139* [1.027,1.263] p = 0.013

DCIS vs. IDC

0.904* [0.830,0.983] p = 0.018

0.967 [0.882,1.060] p = 0.474

1.021 [0.961,1.084] p = 0.509

1.413*** [1.168,1.681] p < 0.001

0.984 [0.924,1.048] p = 0.613

0.967 [0.856,1.092] p = 0.586

1.084 [0.971,1.270] p = 0.150

  1. Logistic regression analysis, reporting odds ratios [95 % confidence intervals]. *p < 0.05, **p < 0.01, ***p < 0.001. Analysis adjusted for menopausal status, age and weight. All cases cohort describes combined IDC (invasive ductal carcinoma) and DCIS (ductal carcinoma in-situ) cases. DMR: differentially methylated region. Chr: chromosome. PLAGL1/ZAC1: Pleomorphic adenoma gene like 1. H19: H19, imprinted maternally expressed non-coding transcript-Imprint control region 1. IGF2: Insulin-like growth factor 2. KvDMR: 11p15 region imprint control region 2. RB1: Retinoblastoma 1. SNRPN: Small nuclear Ribonucleoprotein polypeptide N. PEG3: Paternally expressed gene 3