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Table 4 Different combinations of modified MMSP markers observed in NPC samples selected on the basis that they were EBV (EBNA1)-positive (n = 36) and non-cancerous controls (n = 18) from Morocco

From: Detection of nasopharyngeal carcinoma in Morocco (North Africa) using a multiplex methylation-specific PCR biomarker assay

Marker genes/combinations

1

2

3

4

5

EBNA1

+

+

+

+

+

+

+

+

+

+

+

U-LMP1

-

+

-

+

+

-

-

+

+

-

+

M-ITGA9

-

-

-

+

-

+

-

+

-

+

+

M-RASSF1A

-

-

-

-

+

+

+

+

+

+

+

M-P16

-

-

+

-

-

-

+

-

+

+

+

NPC samples (n = 36)

1

4

1

2

3

2

2

6

5

4

6

Control (n = 18)

0

0

0

0

1

0

0

0

0

0

0

EBNA1 + at least 3 methylation markers

       

Sn: 58 % (21/36)

Sp: 100 % (18/18)

EBNA1 + at least 2 methylation markers

   

Sn: 83 % (30/36)

Sp: 94 % (17/18)

EBNA1 + at least 1 methylation marker

 

Sn: 97 % (35/36)

Sp: 94 % (17/18)