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Fig. 2 | Clinical Epigenetics

Fig. 2

From: 5-Carboxylcytosine levels are elevated in human breast cancers and gliomas

Fig. 2

5caC levels are elevated in a range of human breast cancers. a Fluorescent 5caC and 5hmC immunostaining in normal breast tissue. Individual channels and merged view are shown. b DAB-based 5caC and 5hmC immunostaining in normal breast tissue. c Examples of breast cancer tissue with different levels of 5caC signal (designated as detectable or undetectable) used for the categorization of 5caC staining presented in (d). d Proportions of breast cancers and samples of normal breast tissue with detectable 5caC staining. e Examples of breast cancer tissue with different levels of 5hmC signal (designated as strong, moderate or weak) used for the categorization of 5hmC staining presented in (f). 5hmC staining in 12.5 dpc embryonic brain is shown as a positive control. f Proportions of breast tumours, 5caC positive breast tumours and samples of normal breast tissue exhibiting different levels of 5hmC staining. **p < 0.001

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