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Table 1 Summary of reports indicating that tobacco smoking evokes hypomethylation at single CpG sites in white blood cells

From: A varying T cell subtype explains apparent tobacco smoking induced single CpG hypomethylation in whole blood

Report

Hypomethylationa

Methylation change

 

Maxb

cg19859270c

cg03636183c

% of CpG sites (n)

(%)

Whole blood

 Breitling et al., 2011 [1]

84 (13)

−14

−4.3

−12.6

 Wan et al., 2012 [6]

60 (15)

−8

−2; −2

−8; −6

 Zeilinger et al., 2013 [7]

62 (29)

−25

−1.4; −2

−15; −17

 Shenker et.al., 2013 [3]

83 (36)

−16

n/a

−7; −8

 Sun et al., 2013 [4]

93 (15)

−10

−2.1; −2.2

−9.6; −3

 Tsaprouni et al., 2014 [5]

96 (30)

−28

−3.5; −2.7

−13.4; −10.6

PBMC

 Dogan et al., 2014 [2]

60 (30)

−19

−10

n/a

  1. n/a not available
  2. aDescribes the methylation change in smokers vs. non-smokers of the prominent highlighted single CpGs
  3. bIndicates the maximum of methylation change at single CpG
  4. cHighlighted are values for the main and replicated cohorts of appropriate studies
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Clinical Epigenetics

ISSN: 1868-7083

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