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Table 3 Association between global methylation and breast cancer risk by CpG genomic feature per 1 SD in EPIC

From: Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis

   # CpG loci OR (95 % CI) p value
All Including all probes 408,749 0.61 (0.47–0.80) 0.0004
Excluding SNP probes 360,342 0.62 (0.47–0.81) 0.0004
CpG island Island 124,962 0.76 (0.57–0.99) 0.04
Shores 98,890 0.72 (0.55–0.93) 0.01
Shelves 38,755 0.50 (0.37–0.68) 8.93 × 10−6
None 146,142 0.50 (0.38–0.68) 7.44 × 10−6
Gene region feature category TSS1500 59,494 0.70 (0.53–0.92) 0.01
TSS200 43,506 0.92 (0.69–1.24) 0.60
5′UTR 36,778 0.72 (0.54–0.95) 0.02
1st exon 19,024 0.85 (0.65–1.12) 0.25
Promoter 82,006 0.92 (0.64–1.32) 0.66
Gene body 138,499 0.51 (0.38–0.69) 1.58 × 10−5
UTR3 15,065 0.40 (0.29–0.57) 2.90 × 10−7
Intergenic 96,383 0.57 (0.43–0.75) 6.86 × 10−5