Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes

Clinical Epigenetics

Table 1 Circulating miRs differentially expressed in T2DM patients and healthy subjects

Circulating miRs	Expression in T2DM patients vs. CTR	Sample type	Refs	miR classification
let-7a	Down	Plasma	[96]	O
let-7f	Down	Plasma	[96]	O
let-7i	Down	serum	[97]	O
miR-124a	Up	serum	[98]	I
miR-125b	Down	Plasma	[85]	O, I
miR-126	Down	Plasma	[85]	A, I, O
	Down	Plasma	[99]
	Down	Plasma	[83]
miR-130b	Down	Plasma	[85]	O
miR-140-5p	Up	Plasma	[85]
miR-142-3p	Up	Plasma	[85]	I, O
miR-144	Up	Peripheral blood	[74]	O, I
miR-146a	Up	Serum	[98]	I, A, O
	Up	Plasma	[76]
	Down	Serum	[97]
	Down	Peripheral blood	[74]
	Down	Serum	[75]
miR-150	Up	Peripheral blood	[74]	I, A, O
miR-15a	Down	Plasma	[83]	O
miR-182	Down	Peripheral blood	[74]	O
miR-186	Down	Serum	[97]	O
miR-191	Down	Serum	[97]	O
	Down	Plasma	[83]
miR-192	Down	Plasma	[85]	O
	Down	Serum	[97]
	Up	Peripheral blood	[74]
miR-195	Down	Plasma	[85]	A, O
miR-197	Down	Plasma	[83]	O
miR-199a	Up	Plasma	[100]	O
miR-20b	Down	Plasma	[83]	A, O
miR-21	Down	Plasma	[83]	O, I, A
miR-222	Up	Plasma	[85]	O, A
miR-223	Down	Plasma	[83]	I, O, A
miR-23a	Down	Serum	[97]	O
miR-24	Down	Plasma	[83]	O, I
miR-28-3p	Up	Plasma	[83]
miR-29a	Up	Serum	[98]	O
	Up	Peripheral blood	[74]
miR-29b	Down	Plasma	[83]	O
miR-30d	Up	serum	[98]	O
miR-320a	Down	Plasma	[83]	O
	Up	Peripheral blood	[74]
miR-326	Up	Plasma	[96]	O
miR-34a	Up	Serum	[98]	O, A, I
miR-375	Up	Serum	[98]	O
miR-423-5p	Down	Plasma	[85]
miR-486	Down	Serum	[97]	O
	Down	Plasma	[83]
miR-503	Down	serum	[101]	O, A
	Up	Plasma	[102]
miR-532-5p	Down	Plasma	[85]
miR-9	Up	Serum	[98]	O
miR-96	Down	Serum	[97]	O

CTR, healthy control subjects; I, inflammamiRs; O, oncomiRs; A, angiomiRs. This classification is based on the amount of relative literature, and some miRNAs can be classified in more than one group

ISSN: 1868-7083