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Figure 2 | Clinical Epigenetics

Figure 2

From: Coordinated epigenetic remodelling of transcriptional networks occurs during early breast carcinogenesis

Figure 2

Ingenuity pathway analysis (IPA) identifies deregulation of MYC and EZH2/polycomb in vHMEC. (A) The two most significant gene expression pathways identified by IPA involve deregulation of the proto-oncogene MYC and (B) the epigenetic regulator and member of the polycomb family, EZH2 (shading represents t statistic). (C) Gene set enrichment analysis demonstrates up-regulation of MYC targets and (D) down-regulation of polycomb target genes in vHMEC in a pattern identical to that reported in cancer.

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