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Figure 4 | Clinical Epigenetics

Figure 4

From: Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients

Figure 4

Association between ABCA1 methylation and tumor progression. Dot plot showing the association between ABCA1 methylation in different (A) stages and (B) grades in 76 ovarian cancer patient samples. Methylation of ABCA1 was determined by bisulfite pyro-sequencing. Low stage and low grade represented FIGO I and II and grade 1–2, respectively. While high stage and high grade represented FIGO III and IV and grade 3, respectively. *P < 0.05 by the Mann-Whitney U test. Kaplan-Meier analysis of ABCA1 methylation for (C) progression-free survival and (D) overall survival in 76 ovarian cancer patient samples is shown. Patients were grouped according to methylation of ABCA1 of 3%, which is based on the methylation level of IOSE cells. Patients with “high” ABCA1 methylation (>3% methylation) have significant shorter overall survival (P = 0.019) but not progression-free survival than patients with “low” ABCA1 methylation. Log-rank P values are shown.

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