| |
Adenocarcinoma
|
Squamous Cell Carcinoma
|
|---|
|
CpG site
|
MCaM (N = 535)
|
MCoM (N = 56)
|
P-valuea
|
FDRa
|
ORb
|
P-valueb
|
95% CIb
|
AUCb
|
MCaM (N = 386)
|
MCoM (N = 70)
|
P-valuea
|
FDRa
|
ORb
|
P-valueb
|
95% CIb
|
AUC†
|
|---|
|
cg15020645
|
0.26(40.7%)
|
0.13(0%)
|
3.5 × 10-32
|
1.0 × 10
-31
|
190.6
|
7.7 × 10
-6
|
22.65 to 2,321
|
0.72
|
0.13(14.77%)
|
0.11(0%)
|
0.087466
|
0.131199
|
3.16
|
0.406
|
0.28 to 68.72
|
0.61
|
|
cg16970232
|
0.3(45.2%)
|
0.11(0%)
|
5.0 × 10-38
|
3.0 × 10
-37
|
108.9
|
5.1 × 10
-6
|
17.64 to 1,043
|
0.73
|
0.15(18.91%)
|
0.09(0%)
|
2.7 × 10-7
|
1.6 × 10
-6
|
7.54
|
0.035
|
1.39 to 64.07
|
0.45
|
|
cg20311501
|
0.33(48.4%)
|
0.16(5.3%)
|
1.4 × 10-22
|
2.1 × 10
-22
|
61.56
|
4.96 × 10
-6
|
11.94 to 420
|
0.73
|
0.18(19.95%)
|
0.14(0%)
|
0.001955
|
0.003909
|
2.48
|
0.257
|
0.57 to 13.74
|
0.49
|
|
cg21634602
|
0.33(47.4%)
|
0.16(7.1%)
|
3.6 × 10-17
|
4.3 × 10
-17
|
23.34
|
3.6 × 10
-5
|
5.75 to 116.0
|
0.71
|
0.16(20.47%)
|
0.14(7.14%)
|
0.222306
|
0.266767
|
1.27
|
0.726
|
0.35 to 5.42
|
0.53
|
|
cg24332422
|
0.26(40.5%)
|
0.16(0%)
|
1.0 × 10-26
|
2.0 × 10
-26
|
223.6
|
2.81 × 10
-5
|
21.11 to 3,463
|
0.71
|
0.16(17.36%)
|
0.15(0%)
|
0.338755
|
0.338755
|
1.6
|
0.656
|
0.23 to 14.30
|
0.52
|
- MCaM, MCoM represent the mean of case methylation (Beta) and mean of control methylation (Beta). Methylation levels are calculated with formula: Beta = (M/M + U).
- aP-values are from t-test or Wilcoxon rank-sum test after false discovery rate (FDR adjustment). The t-test will be chose when the variable is normally distributed, or else the rank-sum test will be chose. Significant P-values after FDR are bolded which indicate significant different methylation between case and control.
- bOR and its 95% CI, P-value and AUC from logistic regression analysis or prediction model.
