
Adenocarcinoma

Squamous Cell Carcinoma


CpG site

MCaM (N = 535)

MCoM (N = 56)

Pvalue^{a}

FDR^{a}

OR^{b}

Pvalue^{b}

95% CI^{b}

AUC^{b}

MCaM (N = 386)

MCoM (N = 70)

Pvalue^{a}

FDR^{a}

OR^{b}

Pvalue^{b}

95% CI^{b}

AUC^{†}


cg15020645

0.26(40.7%)

0.13(0%)

3.5 × 10^{32}

1.0 × 10
^{31}

190.6

7.7 × 10
^{6}

22.65 to 2,321

0.72

0.13(14.77%)

0.11(0%)

0.087466

0.131199

3.16

0.406

0.28 to 68.72

0.61

cg16970232

0.3(45.2%)

0.11(0%)

5.0 × 10^{38}

3.0 × 10
^{37}

108.9

5.1 × 10
^{6}

17.64 to 1,043

0.73

0.15(18.91%)

0.09(0%)

2.7 × 10^{7}

1.6 × 10
^{6}

7.54

0.035

1.39 to 64.07

0.45

cg20311501

0.33(48.4%)

0.16(5.3%)

1.4 × 10^{22}

2.1 × 10
^{22}

61.56

4.96 × 10
^{6}

11.94 to 420

0.73

0.18(19.95%)

0.14(0%)

0.001955

0.003909

2.48

0.257

0.57 to 13.74

0.49

cg21634602

0.33(47.4%)

0.16(7.1%)

3.6 × 10^{17}

4.3 × 10
^{17}

23.34

3.6 × 10
^{5}

5.75 to 116.0

0.71

0.16(20.47%)

0.14(7.14%)

0.222306

0.266767

1.27

0.726

0.35 to 5.42

0.53

cg24332422

0.26(40.5%)

0.16(0%)

1.0 × 10^{26}

2.0 × 10
^{26}

223.6

2.81 × 10
^{5}

21.11 to 3,463

0.71

0.16(17.36%)

0.15(0%)

0.338755

0.338755

1.6

0.656

0.23 to 14.30

0.52

 MCaM, MCoM represent the mean of case methylation (Beta) and mean of control methylation (Beta). Methylation levels are calculated with formula: Beta = (M/M + U).
 ^{a}Pvalues are from ttest or Wilcoxon ranksum test after false discovery rate (FDR adjustment). The ttest will be chose when the variable is normally distributed, or else the ranksum test will be chose. Significant Pvalues after FDR are bolded which indicate significant different methylation between case and control.
 ^{b}OR and its 95% CI, Pvalue and AUC from logistic regression analysis or prediction model.