Author
|
Sample type
|
Agea
|
Stages I%
|
Gender (M/F)
|
Patients (M+/M-)
|
Control (M+/M-)
|
Methods
|
Aim
|
Multiple target
|
Ad2Sc
|
Control design
|
Reference
|
---|
Zhang et al. [27]b
|
Tissue
|
59
|
32.05
|
29/39
|
44/34
|
10/68
|
MSP
|
Diagnose
|
Yes
|
0.83
|
hom
|
[27]
|
Wang et al. [25]
|
Tissue
|
-
|
-
|
17/28
|
19/9
|
1/11
|
qMSP
|
Diagnose
|
Yes
|
2.14
|
heter
|
[25]
|
Jin et al. [15]
|
Tissue
|
66.7
|
-
|
17/24
|
27/45
|
22/41
|
qMSP
|
Non-diagnose
|
Yes
|
1.87
|
heter
|
[15]
|
Feng et al. [14]
|
Tissue
|
64.3
|
42.86
|
26/49
|
26/23
|
21/28
|
qMSP
|
Diagnose
|
Yes
|
1.43
|
hom
|
[14]
|
Brabender et al. [13]
|
Tissue
|
63.3
|
49.45
|
69/91
|
86/5
|
80/11
|
qMSP
|
Non-diagnose
|
Single
|
0.77
|
hom
|
[13]
|
Virmani et al. [24]
|
Tissue
|
-
|
-
|
-
|
22/26
|
0/18
|
MSP
|
Diagnose
|
Yes
|
NA
|
heter
|
[24]
|
Yanagawa et al. [26]
|
Tissue
|
67.3
|
66.67
|
18/25
|
28/47
|
36/39
|
MSP
|
Diagnose
|
Yes
|
1.48
|
hom
|
[26]
|
Topaloglu et al. [22]
|
Tissue
|
-
|
54.84
|
-
|
17/14
|
5/17
|
qMSP
|
Diagnose
|
Yes
|
3.00
|
heter
|
[22]
|
Kim et al. [16]
|
Tissue
|
63
|
56.57
|
64/79
|
48/41
|
33/66
|
MSP
|
Non-diagnose
|
Yes
|
0.62
|
hom
|
[16]
|
Vallbohmer et al. [23]
|
Tissue
|
63
|
49.45
|
69/91
|
86/5
|
80/3
|
PCR
|
Non-diagnose
|
Yes
|
0.77
|
hom
|
[23]
|
Lin et al. [17]
|
Tissue
|
61.1
|
100.00
|
20/31
|
49/75
|
2/24
|
MSP
|
Diagnose
|
Yes
|
1.84
|
heter
|
[17]
|
Shivapurkar et al. [20]
|
Tissue
|
-
|
-
|
-
|
35/5
|
23/17
|
qMSP
|
Diagnose
|
Yes
|
1.22
|
heter
|
[20]
|
Suzuki et al. [21]
|
Tissue
|
64
|
34.00
|
33/49
|
53/97
|
3/57
|
MSP
|
Non-diagnose
|
Yes
|
NA
|
heter
|
[21]
|
Zhang et al. [27]b
|
Serum
|
-
|
-
|
-
|
54/56
|
5/45
|
MSP
|
Diagnose
|
Yes
|
NA
|
heter
|
[27]
|
Pan et al. [18]
|
Serum
|
53
|
-
|
17/26
|
40/38
|
0/31
|
qMSP
|
Diagnose
|
Single
|
NA
|
heter
|
[18]
|
Begum et al. [12]
|
Serum
|
65
|
-
|
10/19
|
12/64
|
3/27
|
qMSP
|
Diagnose
|
Yes
|
NA
|
heter
|
[12]
|
Rykova et al. [19]
|
Serum
|
NA
|
-
|
-
|
3/6
|
0/16
|
MSP
|
Diagnose
|
Yes
|
NA
|
heter
|
[19]
|
Usadel et al. [10]
|
Serum
|
64.2
|
-
|
-
|
42/47
|
0/50
|
qMSP
|
Diagnose
|
Single
|
NA
|
heter
|
[10]
|
- amean or median age from articles; bwith two records since there are Tissue and serum data simultaneously in this article. M + and M- means methylation positive and methylation negative, respectively.
- Abbreviations: Ad2Sc, the ratio of adenocarcinoma to squamous cell carcinoma; hom, homogeneous control; heter, heterogeneous control. MSP, qualitative methylation detection method; qMSP, quantitative detection method; Sample type represents the samples analyzed.