Quantitative assessment of the diagnostic role of APC promoter methylation in non-small cell lung cancer

Clinical Epigenetics

Table 1 Characteristics of eligible studies considered in the report

Author	Sample type	Age^a	Stages I%	Gender (M/F)	Patients (M+/M-)	Control (M+/M-)	Methods	Aim	Multiple target	Ad2Sc	Control design	Reference
Zhang et al. [27]^b	Tissue	59	32.05	29/39	44/34	10/68	MSP	Diagnose	Yes	0.83	hom	[27]
Wang et al. [25]	Tissue	-	-	17/28	19/9	1/11	qMSP	Diagnose	Yes	2.14	heter	[25]
Jin et al. [15]	Tissue	66.7	-	17/24	27/45	22/41	qMSP	Non-diagnose	Yes	1.87	heter	[15]
Feng et al. [14]	Tissue	64.3	42.86	26/49	26/23	21/28	qMSP	Diagnose	Yes	1.43	hom	[14]
Brabender et al. [13]	Tissue	63.3	49.45	69/91	86/5	80/11	qMSP	Non-diagnose	Single	0.77	hom	[13]
Virmani et al. [24]	Tissue	-	-	-	22/26	0/18	MSP	Diagnose	Yes	NA	heter	[24]
Yanagawa et al. [26]	Tissue	67.3	66.67	18/25	28/47	36/39	MSP	Diagnose	Yes	1.48	hom	[26]
Topaloglu et al. [22]	Tissue	-	54.84	-	17/14	5/17	qMSP	Diagnose	Yes	3.00	heter	[22]
Kim et al. [16]	Tissue	63	56.57	64/79	48/41	33/66	MSP	Non-diagnose	Yes	0.62	hom	[16]
Vallbohmer et al. [23]	Tissue	63	49.45	69/91	86/5	80/3	PCR	Non-diagnose	Yes	0.77	hom	[23]
Lin et al. [17]	Tissue	61.1	100.00	20/31	49/75	2/24	MSP	Diagnose	Yes	1.84	heter	[17]
Shivapurkar et al. [20]	Tissue	-	-	-	35/5	23/17	qMSP	Diagnose	Yes	1.22	heter	[20]
Suzuki et al. [21]	Tissue	64	34.00	33/49	53/97	3/57	MSP	Non-diagnose	Yes	NA	heter	[21]
Zhang et al. [27]^b	Serum	-	-	-	54/56	5/45	MSP	Diagnose	Yes	NA	heter	[27]
Pan et al. [18]	Serum	53	-	17/26	40/38	0/31	qMSP	Diagnose	Single	NA	heter	[18]
Begum et al. [12]	Serum	65	-	10/19	12/64	3/27	qMSP	Diagnose	Yes	NA	heter	[12]
Rykova et al. [19]	Serum	NA	-	-	3/6	0/16	MSP	Diagnose	Yes	NA	heter	[19]
Usadel et al. [10]	Serum	64.2	-	-	42/47	0/50	qMSP	Diagnose	Single	NA	heter	[10]

^amean or median age from articles; ^bwith two records since there are Tissue and serum data simultaneously in this article. M + and M- means methylation positive and methylation negative, respectively.
Abbreviations: Ad2Sc, the ratio of adenocarcinoma to squamous cell carcinoma; hom, homogeneous control; heter, heterogeneous control. MSP, qualitative methylation detection method; qMSP, quantitative detection method; Sample type represents the samples analyzed.

ISSN: 1868-7083