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Table 1 Characteristics of eligible studies considered in the report

From: Quantitative assessment of the diagnostic role of APC promoter methylation in non-small cell lung cancer

Author Sample type Agea Stages I% Gender (M/F) Patients (M+/M-) Control (M+/M-) Methods Aim Multiple target Ad2Sc Control design Reference
Zhang et al. [27]b Tissue 59 32.05 29/39 44/34 10/68 MSP Diagnose Yes 0.83 hom [27]
Wang et al. [25] Tissue - - 17/28 19/9 1/11 qMSP Diagnose Yes 2.14 heter [25]
Jin et al. [15] Tissue 66.7 - 17/24 27/45 22/41 qMSP Non-diagnose Yes 1.87 heter [15]
Feng et al. [14] Tissue 64.3 42.86 26/49 26/23 21/28 qMSP Diagnose Yes 1.43 hom [14]
Brabender et al. [13] Tissue 63.3 49.45 69/91 86/5 80/11 qMSP Non-diagnose Single 0.77 hom [13]
Virmani et al. [24] Tissue - - - 22/26 0/18 MSP Diagnose Yes NA heter [24]
Yanagawa et al. [26] Tissue 67.3 66.67 18/25 28/47 36/39 MSP Diagnose Yes 1.48 hom [26]
Topaloglu et al. [22] Tissue - 54.84 - 17/14 5/17 qMSP Diagnose Yes 3.00 heter [22]
Kim et al. [16] Tissue 63 56.57 64/79 48/41 33/66 MSP Non-diagnose Yes 0.62 hom [16]
Vallbohmer et al. [23] Tissue 63 49.45 69/91 86/5 80/3 PCR Non-diagnose Yes 0.77 hom [23]
Lin et al. [17] Tissue 61.1 100.00 20/31 49/75 2/24 MSP Diagnose Yes 1.84 heter [17]
Shivapurkar et al. [20] Tissue - - - 35/5 23/17 qMSP Diagnose Yes 1.22 heter [20]
Suzuki et al. [21] Tissue 64 34.00 33/49 53/97 3/57 MSP Non-diagnose Yes NA heter [21]
Zhang et al. [27]b Serum - - - 54/56 5/45 MSP Diagnose Yes NA heter [27]
Pan et al. [18] Serum 53 - 17/26 40/38 0/31 qMSP Diagnose Single NA heter [18]
Begum et al. [12] Serum 65 - 10/19 12/64 3/27 qMSP Diagnose Yes NA heter [12]
Rykova et al. [19] Serum NA - - 3/6 0/16 MSP Diagnose Yes NA heter [19]
Usadel et al. [10] Serum 64.2 - - 42/47 0/50 qMSP Diagnose Single NA heter [10]
  1. amean or median age from articles; bwith two records since there are Tissue and serum data simultaneously in this article. M + and M- means methylation positive and methylation negative, respectively.
  2. Abbreviations: Ad2Sc, the ratio of adenocarcinoma to squamous cell carcinoma; hom, homogeneous control; heter, heterogeneous control. MSP, qualitative methylation detection method; qMSP, quantitative detection method; Sample type represents the samples analyzed.
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