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Figure 2 | Clinical Epigenetics

Figure 2

From: Concomitant downregulation of the imprinted genes DLK1 and MEG3 at 14q32.2 by epigenetic mechanisms in urothelial carcinoma

Figure 2

DLK1 and MEG3 expression in urothelial tissues and cells. Quantitative reverse polymerase chain reaction (RT-PCR) analysis of gene expression relative to the reference gene TBP. (A, C) Boxplot representations of DLK1 (P = 0.004) and MEG3 expression (P = 0.01) in 11 benign (BN) versus 30 cancerous (BT) urothelial tissue samples. (B, D) DLK1 and MEG3 expression in cultured normal urothelial cells (UP) and urothelial carcinoma cell lines (papillary: BC61, BFTC905, J82, RT4, RT112, SW1710; invasive: 5637, 639v, 647v, HT1376, SD, T24, VmCub1, Umuc3) in comparison to HepG2 hepatoma cells. Statistical comparisons between benign bladder and tumor bladder tissue expression were made by the Mann-Whitney U Test with SPSS 21.

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