Figure 2
From: Hypomethylation and overexpression of ITGAL (CD11a) in CD4+ T cells in systemic sclerosis
Schematic representation of the CD11a gene promoter locus. The 23 potentially methylated CpG pairs in the CD11a promoter sequences are identified by the lollipop-shaped figures. The region including Alu elements is denoted by the horizontal line. The transcriptionally relevant PU1, C/EBP, Sp1 transcription factor, ets-related factor, PEBP2/CBF/AML family of transcription factor, RUNX3, and RUNX1/AML-1 transcription factor binding sites and the transcription start site are also shown.